Riaz Ahmed Syed, Dexamathasone Pulse Therapy in Refractory Childhood Seizure Disorders, Journal of Spine and Neuroscience, Volume 1, Issue 1, 2017, Pages 12-15, ISSN 2694-1201, https://doi.org/10.14302/issn.2694-1201.jsn-17-1815.
(https://www.oap-researcharticles.org/spine-and-neuroscience/article/dexamathasone-pulse-therapy-in-refractory-childhood-seizure-disorders-658)
Abstract: 15 children with variable intractable seizure disorders who were on multiple anti-convulsant medications were treated with pulse monthly doses of parenteral dexamethasone varying from 4 – 7 months. EEG and clinical response were assessed periodically as well at the end of the study. 53% of the patients showed clinical response and EEG response. Hypertension was noted in 6, hypokalemia in 3 and hyperglycaemia in 1 patient. The ultimate compliance from the parents for this treatment was seen among 12 patients because of its proven efficacy and parents of seven patients insisted on continuing the treatment for a long duration.
Keywords: Dexamethasone; electroencephalography (EEG); intractable seizures